Concept information
Preferred term
Complement Pathway, Mannose-Binding Lectin
Type
-
mesh:Descriptor
Definition
- Complement activation triggered by the interaction of microbial POLYSACCHARIDES with serum MANNOSE-BINDING LECTIN resulting in the activation of MANNOSE-BINDING PROTEIN-ASSOCIATED SERINE PROTEASES. As in the classical pathway, MASPs cleave COMPLEMENT C4 and COMPLEMENT C2 to form C3 CONVERTASE (C4B2A) and the subsequent C5 CONVERTASE (C4B2A3B) leading to cleavage of COMPLEMENT C5 and assembly of COMPLEMENT MEMBRANE ATTACK COMPLEX.
Broader concept
Entry terms
- Lectin-Complement Pathway
- Mannan-Binding Lectin Complement Pathway
- Mannan-Binding Lectin Pathway (Complement Activation)
- Mannose-Binding Lectin Complement Pathway
Allowable Qualifier(s)
In other languages
-
French
-
Voie d'activation par la lectine liant le mannose
-
Voie de la lectine
-
Voie de la MBL
-
Voie des lectines liant le mannose
-
Voie lectine liant le mannose
URI
http://data.loterre.fr/ark:/67375/JVR-LSV9J3JV-X
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