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... > Heterocyclic Compounds > Heterocyclic Compounds, 1-Ring > Pyridines > Nicotinic Acids > Niacinamide > Sorafenib
Heterocyclic Compounds > Acids, Heterocyclic > Nicotinic Acids > Niacinamide > Sorafenib
... > Organic Chemicals > Hydrocarbons > Hydrocarbons, Cyclic > Hydrocarbons, Aromatic > Benzene Derivatives > Phenylurea Compounds > Sorafenib
Organic Chemicals > Amides > Urea > Phenylurea Compounds > Sorafenib

Preferred term

Sorafenib  

Type

  • mesh:Descriptor

Definition

  • A niacinamide and phenylurea derivative that inhibits multiple intracellular and cell surface kinases thought to be involved in ANGIOGENESIS, including RAF KINASES and VEGF RECEPTORS. It is used in the treatment of advanced RENAL CELL CARCINOMA and HEPATOCELLULAR CARCINOMA, and for treatment of THYROID CARCINOMA refractory to radioactive iodine therapy.

Broader concept

Entry terms

  • 2-Pyridinecarboxamide, 4-(4-((((4-chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-
  • 5T62Q3B36J
  • 5XYK65KIGD
  • 9ZOQ3TZI87

Allowable Qualifier(s)

Pharmacological Action(s)

In other languages

  • Sorafénib

    French

  • 2-Pyridinecarboxamide, 4-(4-((((4-chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-
  • 5T62Q3B36J
  • 5XYK65KIGD
  • 9ZOQ3TZI87

URI

http://data.loterre.fr/ark:/67375/JVR-MBZ72W29-Q

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RDF/XML TURTLE JSON-LD Created 7/9/18, last modified 5/27/20