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Concept information

Metabolism > Pharmacokinetics > Biotransformation > Inactivation, Metabolic > Metabolic Detoxication, Phase I
... > Physiological Phenomena > Pharmacological and Toxicological Phenomena > Pharmacokinetics > Biotransformation > Inactivation, Metabolic > Metabolic Detoxication, Phase I

Preferred term

Metabolic Detoxication, Phase I  

Type

  • mesh:Descriptor

Definition

  • Functionalization of exogenous substances to prepare them for conjugation in PHASE II DETOXIFICATION. Phase I enzymes include CYTOCHROME P450 enzymes and some OXIDOREDUCTASES. Excess induction of phase I over phase II detoxification leads to higher levels of FREE RADICALS that can induce CANCER and other cell damage. Induction or antagonism of phase I detoxication is the basis of a number of DRUG INTERACTIONS.

Broader concept

Related concepts

Entry terms

  • Metabolic Detoxication, Oxidative
  • Metabolic Detoxification, Phase I
  • Phase I Detoxification

Allowable Qualifier(s)

In other languages

  • Détoxication de phase I

    French

  • Détoxication métabolique de phase I
  • Détoxication oxydative
  • Détoxication par oxydation
  • Détoxification de phase I
  • Détoxification métabolique de phase I
  • Détoxification oxydative
  • Détoxification par oxydation

URI

http://data.loterre.fr/ark:/67375/JVR-MD3PXP2B-J

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RDF/XML TURTLE JSON-LD Created 6/30/05, last modified 6/30/16