: MeSH: Sneddon Syndrome

Skin and Connective Tissue Diseases > Skin Diseases > Skin Diseases, Vascular > Sneddon Syndrome

Cardiovascular Diseases > Vascular Diseases > Cerebrovascular Disorders > Sneddon Syndrome

Nervous System Diseases > Central Nervous System Diseases > Brain Diseases > Cerebrovascular Disorders > Sneddon Syndrome

Sneddon Syndrome

A systemic non-inflammatory arteriopathy primarily of middle-aged females characterized by the association of LIVEDO RETICULARIS, multiple thrombotic CEREBRAL INFARCTION; CORONARY DISEASE, and HYPERTENSION. Elevation of antiphospholipid antibody titers (see also ANTIPHOSPHOLIPID SYNDROME), cardiac valvulopathy, ISCHEMIC ATTACK, TRANSIENT; SEIZURES; DEMENTIA; and chronic ischemia of the extremities may also occur. Pathologic examination of affected arteries reveals non-inflammatory adventitial fibrosis, thrombosis, and changes in the media. (From Jablonski, Dictionary of Syndromes & Eponymic Diseases, 2d ed; Adams et al., Principles of Neurology, 6th ed, p861; Arch Neurol 1997 Jan;54(1):53-60)

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