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Concept information

... > Amino Acids, Peptides, and Proteins > Proteins > Membrane Proteins > Receptors, Cell Surface > Receptor Protein-Tyrosine Kinases > Anaplastic Lymphoma Kinase
... > Amino Acids, Peptides, and Proteins > Peptides > Intracellular Signaling Peptides and Proteins > Protein-Tyrosine Kinases > Receptor Protein-Tyrosine Kinases > Anaplastic Lymphoma Kinase
... > Amino Acids, Peptides, and Proteins > Proteins > Intracellular Signaling Peptides and Proteins > Protein-Tyrosine Kinases > Receptor Protein-Tyrosine Kinases > Anaplastic Lymphoma Kinase
... > Enzymes and Coenzymes > Enzymes > Transferases > Phosphotransferases > Phosphotransferases (Alcohol Group Acceptor) > Protein Kinases > Protein-Tyrosine Kinases > Receptor Protein-Tyrosine Kinases > Anaplastic Lymphoma Kinase

Preferred term

Anaplastic Lymphoma Kinase  

Type

  • mesh:Descriptor

Definition

  • A receptor tyrosine kinase that is essential for development and differentiation of the nervous system in response to secreted growth factors. It phosphorylates the first tyrosine of the Y-x-x-x-Y-Y motif of targets that include PROTO-ONCOGENE PROTEINS C-CBL; INSULIN RECEPTOR SUBSTRATE-1; and MITOGEN-ACTIVATED PROTEIN KINASES, leading to activation of the MAPK signaling pathway and cell proliferation. A chromosomal aberration involving the ALK gene results in its constitutive expression in some cases of NON-HODGKIN LYMPHOMA.

Broader concept

Entry terms

  • ALK Kinase
  • ALK Tyrosine Kinase Receptor
  • Anaplastic Lymphoma Receptor Tyrosine Kinase
  • CD246 Antigen
  • NPM-ALK
  • Nucleophosmin-Anaplastic Lymphoma Kinase

Allowable Qualifier(s)

In other languages

  • Kinase du lymphome anaplasique

    French

  • ALK Kinase
  • Anaplastic lymphoma kinase
  • Antigène CD246
  • CD246
  • Kinase ALK
  • NPM-ALK
  • Nucléophosmine-kinase du lymphome anaplasique
  • Récepteur à activité tyrosine kinase du lymphome anaplasique
  • Récepteur à tyrosine kinase ALK
  • Récepteur à tyrosine kinase du lymphome anaplasique

URI

http://data.loterre.fr/ark:/67375/JVR-MZ07F2NX-6

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RDF/XML TURTLE JSON-LD Created 7/9/18, last modified 5/20/21