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Concept information

Amino Acids, Peptides, and Proteins > Peptides > Intracellular Signaling Peptides and Proteins > Protein Serine-Threonine Kinases > Checkpoint Kinase 1
Amino Acids, Peptides, and Proteins > Proteins > Intracellular Signaling Peptides and Proteins > Protein Serine-Threonine Kinases > Checkpoint Kinase 1
... > Enzymes and Coenzymes > Enzymes > Transferases > Phosphotransferases > Phosphotransferases (Alcohol Group Acceptor) > Protein Kinases > Protein Serine-Threonine Kinases > Checkpoint Kinase 1

Preferred term

Checkpoint Kinase 1  

Type

  • mesh:Descriptor

Definition

  • A serine/threonine-specific protein kinase which is encoded by the CHEK1 gene in humans. Checkpoint kinase 1 (also known as Chk1) coordinates DNA damage response and cell cycle checkpoint response. Under these conditions, activation of Chk1 results in the initiation of cell cycle checkpoints, cell cycle arrest, DNA repair and cell death, to prevent damaged cells from progressing through the cell cycle.

Broader concept

Entry terms

  • Checkpoint-1 Kinase
  • Chk1 Kinase
  • Chk1 Protein Kinase

Allowable Qualifier(s)

In other languages

  • Checkpoint kinase 1

    French

  • Kinase Chk1
  • Kinase-1 de point de contrôle
  • Kinase-1 du point de contrôle
  • Protéine kinase Chk1

URI

http://data.loterre.fr/ark:/67375/JVR-N2CPS7HB-8

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RDF/XML TURTLE JSON-LD Created 7/8/16, last modified 5/21/21