Concept information
Preferred term
Tolcapone
Type
-
mesh:Descriptor
Definition
- A benzophenone and nitrophenol compound that acts as an inhibitor of CATECHOL O-METHYLTRANSFERASE, an enzyme involved in the metabolism of DOPAMINE and LEVODOPA. It is used in the treatment of PARKINSON DISEASE in patients for whom levodopa is ineffective or contraindicated.
Broader concept
Entry terms
- 134308-13-7 (Tolcapone)
- CIF6334OLY
- Methanone, (3,4-dihydroxy-5-nitrophenyl)(4-methylphenyl)-
Allowable Qualifier(s)
- administration & dosage (Qualifier)
- adverse effects (Qualifier)
- agonists (Qualifier)
- analogs & derivatives (Qualifier)
- analysis (Qualifier)
- antagonists & inhibitors (Qualifier)
- blood (Qualifier)
- cerebrospinal fluid (Qualifier)
- chemical synthesis (Qualifier)
- chemistry (Qualifier)
- classification (Qualifier)
- economics (Qualifier)
- history (Qualifier)
- immunology (Qualifier)
- isolation & purification (Qualifier)
- metabolism (Qualifier)
- pharmacokinetics (Qualifier)
- pharmacology (Qualifier)
- poisoning (Qualifier)
- radiation effects (Qualifier)
- standards (Qualifier)
- supply & distribution (Qualifier)
- therapeutic use (Qualifier)
- toxicity (Qualifier)
- urine (Qualifier)
Pharmacological Action(s)
In other languages
-
French
-
134308-13-7 (Tolcapone)
-
CIF6334OLY
-
Methanone, (3,4-dihydroxy-5-nitrophenyl)(4-methylphenyl)-
URI
http://data.loterre.fr/ark:/67375/JVR-N3T9ZCDW-L
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