Concept information
Preferred term
Pregnane X Receptor
Type
-
mesh:Descriptor
Definition
- Steroid receptor that binds and is activated by variety of endogenous compounds and XENOBIOTICS. It binds the response element in promoters of genes that encode CYTOCHROME P450 3A4 and ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1 proteins, and also activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs, and endogenous compounds. It is activated by the antibiotic RIFAMPICIN and various plant metabolites, such as hyperforin, guggulipid, colupulone, and ISOFLAVONES.
Broader concept
Entry terms
- NR1I2
- Nuclear Receptor Subfamily 1, Group I, Member 2
- Steroid and Xenobiotic Receptor
- Steroid X Receptor
- SXR Receptor
Allowable Qualifier(s)
- administration & dosage (Qualifier)
- agonists (Qualifier)
- analysis (Qualifier)
- antagonists & inhibitors (Qualifier)
- biosynthesis (Qualifier)
- blood (Qualifier)
- chemistry (Qualifier)
- classification (Qualifier)
- deficiency (Qualifier)
- drug effects (Qualifier)
- genetics (Qualifier)
- history (Qualifier)
- immunology (Qualifier)
- isolation & purification (Qualifier)
- metabolism (Qualifier)
- physiology (Qualifier)
- radiation effects (Qualifier)
- therapeutic use (Qualifier)
- ultrastructure (Qualifier)
In other languages
-
French
-
Membre-2 du groupe I de la sous-famille-1 de récepteurs nucléaires
-
NR1I2
-
Récepteur des stéroïdes et des xénobiotiques
-
Récepteur des stéroïdes et xénobiotiques
-
Récepteur prégnane X
-
Récepteur SXR
URI
http://data.loterre.fr/ark:/67375/JVR-N4WFTJ0T-D
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