: MeSH: Cytochrome-B(5) Reductase

Amino Acids, Peptides, and Proteins > Proteins > Flavoproteins > Cytochrome-B(5) Reductase

... > Enzymes > Oxidoreductases > NADH, NADPH Oxidoreductases > Cytochrome Reductases > Cytochrome-B(5) Reductase

Cytochrome-B(5) Reductase

A FLAVOPROTEIN oxidoreductase that occurs both as a soluble enzyme and a membrane-bound enzyme due to ALTERNATIVE SPLICING of a single mRNA. The soluble form is present mainly in ERYTHROCYTES and is involved in the reduction of METHEMOGLOBIN. The membrane-bound form of the enzyme is found primarily in the ENDOPLASMIC RETICULUM and outer mitochondrial membrane, where it participates in the desaturation of FATTY ACIDS; CHOLESTEROL biosynthesis and drug metabolism. A deficiency in the enzyme can result in METHEMOGLOBINEMIA. The soluble, erythrocyte form of cytochrome-B(5) reductase. It catalyzes the reduction of methemoglobin (ferrihemoglobin) to hemoglobin (ferrohemoglobin).

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