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... > Chemical Phenomena > Biochemical Phenomena > Molecular Structure > Molecular Conformation > Protein Conformation > Protein Structural Elements > Protein Domains > Protein Interaction Domains and Motifs > Death Domain Superfamily > Caspase Activation and Recruitment Domain
... > Chemical Phenomena > Biochemical Phenomena > Molecular Structure > Molecular Conformation > Protein Conformation > Protein Structure, Tertiary > Protein Domains > Protein Interaction Domains and Motifs > Death Domain Superfamily > Caspase Activation and Recruitment Domain

Preferred term

Caspase Activation and Recruitment Domain  

Type

  • mesh:Descriptor

Definition

  • A homotypic protein interaction module of the death domain superfamily. It is composed of a bundle of six alpha-helices that is related in sequence and structure to the DEATH DOMAIN and DEATH EFFECTOR DOMAIN. The Caspase Activation and Recruitment Domain (CARD domain) typically associates with other CARD-containing proteins, forming either dimers or trimers. CARD domains may occur in isolation, or in combination with other domains in CARD signaling adaptor proteins and initiator CASPASES that function in APOPTOSIS.

Broader concept

Related concepts

Entry terms

  • CARD Domain
  • CARD Domains
  • Caspase Activation and Recruitment Domains
  • Caspase Recruitment Domain
  • Caspase Recruitment Domains

Allowable Qualifier(s)

In other languages

URI

http://data.loterre.fr/ark:/67375/JVR-NMDP49CZ-P

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RDF/XML TURTLE JSON-LD Created 7/8/16, last modified 5/9/16