: MeSH: Shy-Drager Syndrome

... > Central Nervous System Diseases > Brain Diseases > Basal Ganglia Diseases > Multiple System Atrophy > Shy-Drager Syndrome

Nervous System Diseases > Central Nervous System Diseases > Movement Disorders > Multiple System Atrophy > Shy-Drager Syndrome

Nervous System Diseases > Autonomic Nervous System Diseases > Primary Dysautonomias > Multiple System Atrophy > Shy-Drager Syndrome

... > Metabolic Diseases > Proteostasis Deficiencies > Synucleinopathies > Multiple System Atrophy > Shy-Drager Syndrome

Nervous System Diseases > Neurodegenerative Diseases > Synucleinopathies > Multiple System Atrophy > Shy-Drager Syndrome

Cardiovascular Diseases > Vascular Diseases > Hypotension > Shy-Drager Syndrome

Shy-Drager Syndrome

A progressive neurodegenerative condition of the central and autonomic nervous systems characterized by atrophy of the preganglionic lateral horn neurons of the thoracic spinal cord. This disease is generally considered a clinical variant of MULTIPLE SYSTEM ATROPHY. Affected individuals present in the fifth or sixth decade with ORTHOSTASIS and bladder dysfunction; and later develop FECAL INCONTINENCE; anhidrosis; ATAXIA; IMPOTENCE; and alterations of tone suggestive of basal ganglia dysfunction. (From Adams et al., Principles of Neurology, 6th ed, p536)

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