Skip to main content

Medical Subject Headings (thesaurus)

Search from vocabulary

align
annotate
download

Concept information

Amino Acids, Peptides, and Proteins > Peptides > Intracellular Signaling Peptides and Proteins > Cyclin-Dependent Kinase Inhibitor Proteins
Amino Acids, Peptides, and Proteins > Proteins > Intracellular Signaling Peptides and Proteins > Cyclin-Dependent Kinase Inhibitor Proteins
Amino Acids, Peptides, and Proteins > Proteins > Neoplasm Proteins > Tumor Suppressor Proteins > Cyclin-Dependent Kinase Inhibitor Proteins
Amino Acids, Peptides, and Proteins > Proteins > Cell Cycle Proteins > Cyclin-Dependent Kinase Inhibitor Proteins

Preferred term

Cyclin-Dependent Kinase Inhibitor Proteins  

Type

  • mesh:Descriptor

Definition

  • A group of cell cycle proteins that negatively regulate the activity of CYCLIN/CYCLIN-DEPENDENT KINASE complexes. They inhibit CELL CYCLE progression and help control CELL PROLIFERATION following GENOTOXIC STRESS as well as during CELL DIFFERENTIATION. A family of cell cycle proteins containing ANKYRIN REPEATS that are specific inhibitors of cyclin D-dependent kinases. INK4 proteins bind to CYCLIN-DEPENDENT KINASE 4 and CYCLIN-DEPENDENT KINASE 6. They dissociate cyclin-CDK complexes and regulate a CELL CYCLE checkpoint in early G1 PHASE.

Broader concept

Narrower concepts

Entry terms

  • CDKI Proteins
  • CKI Proteins
  • Cyclin-Kinase Inhibitor Proteins

Allowable Qualifier(s)

Pharmacological Action(s)

In other languages

  • Protéines inhibitrices des kinases cyclines-dépendantes

    French

  • CDKI
  • CKI (Cyclin-dependent Kinase Inhibitor)
  • CKI (Cyclin-Kinase Inhibitor)
  • Cyclin-dependent kinase inhibitor
  • Cyclin-kinase inhibitor
  • Protéines CDKI
  • Protéines CKI
  • Protéines inhibitrices des CDK
  • Protéines inhibitrices des kinases dépendantes des cyclines

URI

http://data.loterre.fr/ark:/67375/JVR-P5K3DBDP-J

Download this concept:

RDF/XML TURTLE JSON-LD Created 6/30/05, last modified 11/23/15