Concept information
Preferred term
Receptors, LDL
Type
-
mesh:Descriptor
Definition
- Receptors on the plasma membrane of nonhepatic cells that specifically bind LDL. The receptors are localized in specialized regions called coated pits. Hypercholesteremia is caused by an allelic genetic defect of three types: 1, receptors do not bind to LDL; 2, there is reduced binding of LDL; and 3, there is normal binding but no internalization of LDL. In consequence, entry of cholesterol esters into the cell is impaired and the intracellular feedback by cholesterol on 3-hydroxy-3-methylglutaryl CoA reductase is lacking.
Broader concept
Narrower concepts
Entry terms
- LDL Receptor
- LDL Receptors
- LDL Receptors, Lipoprotein
- Lipoprotein LDL Receptors
- Low Density Lipoprotein Receptor
- Low Density Lipoprotein Receptors
- Receptors, Lipoprotein, LDL
- Receptors, Low Density Lipoprotein
Allowable Qualifier(s)
- administration & dosage (Qualifier)
- agonists (Qualifier)
- analysis (Qualifier)
- antagonists & inhibitors (Qualifier)
- biosynthesis (Qualifier)
- blood (Qualifier)
- chemistry (Qualifier)
- classification (Qualifier)
- deficiency (Qualifier)
- drug effects (Qualifier)
- genetics (Qualifier)
- history (Qualifier)
- immunology (Qualifier)
- isolation & purification (Qualifier)
- metabolism (Qualifier)
- physiology (Qualifier)
- radiation effects (Qualifier)
- therapeutic use (Qualifier)
- ultrastructure (Qualifier)
In other languages
-
French
-
Récepteurs aux LDL
-
Récepteurs aux lipoprotéines de basse densité
-
Récepteurs aux lipoprotéines de faible densité
-
Récepteurs des LDL
-
Récepteurs des lipoprotéines LDL
-
Récepteurs LDLR
URI
http://data.loterre.fr/ark:/67375/JVR-P85MNZ1S-1
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