Concept information
Preferred term
P-type ATPases
Type
-
mesh:Descriptor
Definition
- A highly conserved family of ATPases that facilitate the transport of lipids and cations across the plasma membrane. Structurally, they are elongated ALPHA-HELICES constituting five functionally distinct domains: three cytoplasmic domains A, N, and P which contain the catalytic sites, and two transmembrane domains. The N domain phosphorylates the P-domain at an invariant ASPARTATE residue, which, in turn, is dephosphorylated by the A domain. The phosphorylation and dephosphorylation cycles drive conformational changes in the protein between two states (E1 and E2), which allow the substrate to access the other side of the membrane.
Broader concept
Narrower concepts
Entry terms
- E1-E2 ATPase
- E1-E2 ATPases
- Phosphorylation-type Adenosine Triphosphatases
- Phosphorylation-type ATPases
- P-type Adenosine Triphosphatase
- P-type Adenosine Triphosphatases
- P Type Atpase
- P-type ATPase
Allowable Qualifier(s)
- administration & dosage (Qualifier)
- adverse effects (Qualifier)
- analysis (Qualifier)
- antagonists & inhibitors (Qualifier)
- biosynthesis (Qualifier)
- blood (Qualifier)
- cerebrospinal fluid (Qualifier)
- chemical synthesis (Qualifier)
- chemistry (Qualifier)
- classification (Qualifier)
- deficiency (Qualifier)
- drug effects (Qualifier)
- economics (Qualifier)
- genetics (Qualifier)
- history (Qualifier)
- immunology (Qualifier)
- isolation & purification (Qualifier)
- metabolism (Qualifier)
- pharmacokinetics (Qualifier)
- pharmacology (Qualifier)
- physiology (Qualifier)
- poisoning (Qualifier)
- radiation effects (Qualifier)
- standards (Qualifier)
- supply & distribution (Qualifier)
- therapeutic use (Qualifier)
- toxicity (Qualifier)
- ultrastructure (Qualifier)
- urine (Qualifier)
In other languages
-
French
-
Adénosine triphosphatases de type P
-
Adénosine triphosphatases de type phosphorylation
-
ATPases de type P
-
ATPases de type phosphorylation
-
ATPases E1-E2
-
E1-E2 ATPases
-
P-type adenosine triphosphatases
-
Phosphorylation-type adenosine triphosphatase
-
Phosphorylation-type ATPase
URI
http://data.loterre.fr/ark:/67375/JVR-PJZ1DD04-8
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