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Nucleic Acids, Nucleotides, and Nucleosides > Nucleosides > Deoxyribonucleosides > Dideoxynucleosides > Zidovudine
... > Carbohydrates > Glycosides > Nucleosides > Deoxyribonucleosides > Dideoxynucleosides > Zidovudine
Nucleic Acids, Nucleotides, and Nucleosides > Nucleosides > Deoxyribonucleosides > Thymidine > Zidovudine
... > Carbohydrates > Glycosides > Nucleosides > Deoxyribonucleosides > Thymidine > Zidovudine
... > Heterocyclic Compounds > Heterocyclic Compounds, 1-Ring > Pyrimidines > Pyrimidine Nucleosides > Thymidine > Zidovudine
Nucleic Acids, Nucleotides, and Nucleosides > Nucleosides > Pyrimidine Nucleosides > Thymidine > Zidovudine
... > Carbohydrates > Glycosides > Nucleosides > Pyrimidine Nucleosides > Thymidine > Zidovudine

Preferred term

Zidovudine  

Type

  • mesh:Descriptor

Definition

  • A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia.

Broader concept

Entry terms

  • 30516-87-1 (Zidovudine)
  • 3'-Azido-2',3'-Dideoxythymidine
  • 3'-Azido-3'-deoxythymidine
  • 4B9XT59T7S
  • Azidothymidine
  • AZT (Antiviral)
  • AZT Antiviral
  • AZT, Antiviral
  • Thymidine, 3'-azido-3'-deoxy-

Allowable Qualifier(s)

Pharmacological Action(s)

In other languages

  • Zidovudine

    French

  • 3'-Azido-3'-désoxy-thymidine
  • 3'-Azido-3'-désoxythymidine
  • 30516-87-1 (Zidovudine)
  • 4B9XT59T7S
  • Azidothymidine
  • AZT (Azidothymidine)
  • Thymidine, 3'-azido-3'-deoxy-

URI

http://data.loterre.fr/ark:/67375/JVR-PLNR7NBH-G

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