: MeSH: Erythrocyte Aggregation

Circulatory and Respiratory Physiological Phenomena > Cardiovascular Physiological Phenomena > Hemodynamics > Hemorheology > Erythrocyte Aggregation

Circulatory and Respiratory Physiological Phenomena > Blood Physiological Phenomena > Hemorheology > Erythrocyte Aggregation

Investigative Techniques > Rheology > Hemorheology > Erythrocyte Aggregation

Natural Science Disciplines > Physics > Rheology > Hemorheology > Erythrocyte Aggregation

Diagnosis > Diagnostic Techniques and Procedures > Clinical Laboratory Techniques > Hematologic Tests > Erythrocyte Aggregation

Investigative Techniques > Clinical Laboratory Techniques > Hematologic Tests > Erythrocyte Aggregation

Erythrocyte Aggregation

The formation of clumps of RED BLOOD CELLS under low or non-flow conditions, resulting from the attraction forces between the red blood cells. The cells adhere to each other in rouleaux aggregates. Slight mechanical force, such as occurs in the circulation, is enough to disperse these aggregates. Stronger or weaker than normal aggregation may result from a variety of effects in the ERYTHROCYTE MEMBRANE or in BLOOD PLASMA. The degree of aggregation is affected by ERYTHROCYTE DEFORMABILITY, erythrocyte membrane sialylation, masking of negative surface charge by plasma proteins, etc. BLOOD VISCOSITY and the ERYTHROCYTE SEDIMENTATION RATE are affected by the amount of erythrocyte aggregation and are parameters used to measure the aggregation. Clumping of ERYTHROCYTES, in vivo, in intact blood vessels. Increased and/or abnormal aggregation may lead to impairment of MICROCIRCULATION (blood sludging and THROMBUS formation) and development of VASCULAR DISEASES. The clumping of ERYTHROCYTES that is like a stack or roll of coins. Aggregation of ERYTHROCYTES in vivo, caused by specific interactions such as those induced by antibodies.

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