Skip to main content

Medical Subject Headings (thesaurus)

Search from vocabulary

align
annotate
download

Concept information

... > Amino Acids, Peptides, and Proteins > Peptides > Intracellular Signaling Peptides and Proteins > Adaptor Proteins, Signal Transducing > Shc Signaling Adaptor Proteins > Src Homology 2 Domain-Containing, Transforming Protein 1
... > Amino Acids, Peptides, and Proteins > Proteins > Intracellular Signaling Peptides and Proteins > Adaptor Proteins, Signal Transducing > Shc Signaling Adaptor Proteins > Src Homology 2 Domain-Containing, Transforming Protein 1
... > Amino Acids, Peptides, and Proteins > Proteins > Carrier Proteins > Adaptor Proteins, Signal Transducing > Shc Signaling Adaptor Proteins > Src Homology 2 Domain-Containing, Transforming Protein 1

Preferred term

Src Homology 2 Domain-Containing, Transforming Protein 1  

Type

  • mesh:Descriptor

Definition

  • An SHC-signaling adaptor protein that transduces PHOSPHOTYROSINE-dependent signals downstream of RECEPTOR PROTEIN-TYROSINE KINASES and non-receptor tyrosine kinases. It is required for TGF-BETA-induced CELL MIGRATION; NEOLPASM INVASION; and METASTASIS of BREAST NEOPLASMS; its SH2 DOMAIN is essential for tumor survival. It also functions in signaling downstream of ANGIOPOIETIN RECEPTOR TIE-2, regulating the migration of ENDOTHELIAL CELLS; and PHYSIOLOGIC NEOVASCULARIZATION.

Broader concept

Entry terms

  • SHC1 Protein
  • SHC1 (Src Homology 2 Domain-Containing) Protein
  • ShcA Protein
  • SHC (Src Homology 2 Domain-Containing) Transforming Protein 1
  • SHC-Transforming Protein 1
  • Src Homology 2 Domain-Containing-Transforming Protein C1

Allowable Qualifier(s)

In other languages

  • Protéine transformante-1 contenant un domaine d'homologie-2 de Src

    French

  • Protéine SHC1
  • Protéine SHC1 (contenant un domaine d'homologie-2 de Src)
  • Protéine ShcA
  • Protéine transformante C1 contenant un domaine d'homologie-2 de Src
  • Protéine transformante SHC1
  • Protéine transformante-1 contenant un domaine d'homologie de type 2 avec Src
  • Protéine transformante-1 SHC
  • Protéine transformante-1 SHC (contenant un domaine d'homologie-2 de Src)

URI

http://data.loterre.fr/ark:/67375/JVR-PS467ZK8-K

Download this concept:

RDF/XML TURTLE JSON-LD Created 7/8/16, last modified 4/15/16