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... > Amino Acids, Peptides, and Proteins > Proteins > Blood Proteins > Immunoproteins > Complement System Proteins > Complement Activating Enzymes > Complement C3-C5 Convertases
Enzymes and Coenzymes > Enzymes > Hydrolases > Complement Activating Enzymes > Complement C3-C5 Convertases

Preferred term

Complement C3-C5 Convertases  

Type

  • mesh:Descriptor

Definition

  • Serine proteases that cleave COMPLEMENT C3 into COMPLEMENT C3A and COMPLEMENT C3B, or cleave COMPLEMENT C5 into COMPLEMENT C5A and COMPLEMENT C5B. These include the different forms of C3/C5 convertases in the classical and the alternative pathways of COMPLEMENT ACTIVATION. Both cleavages take place at the C-terminal of an ARGININE residue. Serine proteases that cleaves C3 at the carboxyl of Arg-77 of the alpha-chain to yield COMPLEMENT 3A and COMPLEMENT 3B in either the classical or the alternative pathways of COMPLEMENT ACTIVATION. Serine proteases that cleaves C5 at the carboxyl of Arg-74 of the alpha-chain to yield COMPLEMENT 5A and COMPLEMENT 5B in either the classical or the alternative pathways of COMPLEMENT ACTIVATION.

Broader concept

Narrower concepts

Entry terms

  • C3-C5 Convertase

Allowable Qualifier(s)

Pharmacological Action(s)

In other languages

URI

http://data.loterre.fr/ark:/67375/JVR-PTQTZ54C-L

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RDF/XML TURTLE JSON-LD Created 6/30/05, last modified 7/5/06