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Amino Acids, Peptides, and Proteins > Proteins > Membrane Proteins > Heterotrimeric GTP-Binding Proteins > Transducin
... > Amino Acids, Peptides, and Proteins > Peptides > Intracellular Signaling Peptides and Proteins > GTP-Binding Proteins > Heterotrimeric GTP-Binding Proteins > Transducin
... > Amino Acids, Peptides, and Proteins > Proteins > Intracellular Signaling Peptides and Proteins > GTP-Binding Proteins > Heterotrimeric GTP-Binding Proteins > Transducin
... > Amino Acids, Peptides, and Proteins > Proteins > Carrier Proteins > GTP-Binding Proteins > Heterotrimeric GTP-Binding Proteins > Transducin
... > Enzymes and Coenzymes > Enzymes > Hydrolases > Acid Anhydride Hydrolases > GTP Phosphohydrolases > GTP-Binding Proteins > Heterotrimeric GTP-Binding Proteins > Transducin

Preferred term

Transducin  

Type

  • mesh:Descriptor

Definition

  • A heterotrimeric GTP-binding protein that mediates the light activation signal from photolyzed rhodopsin to cyclic GMP phosphodiesterase and is pivotal in the visual excitation process. Activation of rhodopsin on the outer membrane of rod and cone cells causes GTP to bind to transducin followed by dissociation of the alpha subunit-GTP complex from the beta/gamma subunits of transducin. The alpha subunit-GTP complex activates the cyclic GMP phosphodiesterase which catalyzes the hydrolysis of cyclic GMP to 5'-GMP. This leads to closure of the sodium and calcium channels and therefore hyperpolarization of the rod cells.

Broader concept

Entry terms

  • G-Protein, Inhibitory Gt
  • Gt, Transducin G-Protein
  • Transducin G-Protein (Gt)

Allowable Qualifier(s)

In other languages

URI

http://data.loterre.fr/ark:/67375/JVR-Q8HD39DL-8

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RDF/XML TURTLE JSON-LD Created 5/24/88, last modified 5/21/21