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Nucleic Acids, Nucleotides, and Nucleosides > Nucleosides > Deoxyribonucleosides > Dideoxynucleosides > Didanosine
... > Carbohydrates > Glycosides > Nucleosides > Deoxyribonucleosides > Dideoxynucleosides > Didanosine
Nucleic Acids, Nucleotides, and Nucleosides > Nucleosides > Purine Nucleosides > Inosine > Didanosine
... > Carbohydrates > Glycosides > Nucleosides > Purine Nucleosides > Inosine > Didanosine
... > Heterocyclic Compounds > Heterocyclic Compounds, Fused-Ring > Heterocyclic Compounds, 2-Ring > Purines > Purine Nucleosides > Inosine > Didanosine
Nucleic Acids, Nucleotides, and Nucleosides > Nucleosides > Ribonucleosides > Inosine > Didanosine
... > Carbohydrates > Glycosides > Nucleosides > Ribonucleosides > Inosine > Didanosine

Preferred term

Didanosine  

Type

  • mesh:Descriptor

Definition

  • A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase; ddI is then metabolized to dideoxyadenosine triphosphate, its putative active metabolite.

Broader concept

Entry terms

  • 2',3'-Dideoxyinosine
  • 69655-05-6 (Didanosine)
  • ddI (Antiviral)
  • Dideoxyinosine
  • Inosine, 2',3'-dideoxy-
  • K3GDH6OH08

Allowable Qualifier(s)

Pharmacological Action(s)

In other languages

  • Didéoxyinosine

    French

  • 69655-05-6 (Didanosine)
  • Inosine, 2',3'-dideoxy-
  • K3GDH6OH08

URI

http://data.loterre.fr/ark:/67375/JVR-QCB4LNZG-H

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RDF/XML TURTLE JSON-LD Created 7/14/89, last modified 5/24/17