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Chemically-Induced Disorders > Poisoning > Neurotoxicity Syndromes > MPTP Poisoning
Nervous System Diseases > Neurotoxicity Syndromes > MPTP Poisoning
... > Nervous System Diseases > Central Nervous System Diseases > Brain Diseases > Basal Ganglia Diseases > Parkinsonian Disorders > Parkinson Disease, Secondary > MPTP Poisoning
... > Nervous System Diseases > Central Nervous System Diseases > Movement Disorders > Parkinsonian Disorders > Parkinson Disease, Secondary > MPTP Poisoning

Preferred term

MPTP Poisoning  

Type

  • mesh:Descriptor

Definition

  • A condition caused by the neurotoxin MPTP which causes selective destruction of nigrostriatal dopaminergic neurons. Clinical features include irreversible parkinsonian signs including rigidity and bradykinesia (PARKINSON DISEASE, SECONDARY). MPTP toxicity is also used as an animal model for the study of PARKINSON DISEASE. (Adams et al., Principles of Neurology, 6th ed, p1072; Neurology 1986 Feb;36(2):250-8)

Broader concept

Related concepts

Entry terms

  • MPTP-Induced Parkinsonism
  • MPTP Neurotoxicity Syndrome
  • Neurotoxicity Syndrome, MPTP
  • Poisoning, 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

Allowable Qualifier(s)

In other languages

  • Intoxication au MPTP

    French

  • Intoxication due au 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
  • Neurotoxicité induite par le MPTP
  • Parkinsonisme dû au MPTP

URI

http://data.loterre.fr/ark:/67375/JVR-QNQ8NHC2-R

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