Concept information
Preferred term
Neprilysin
Type
-
mesh:Descriptor
Definition
- Enzyme that is a major constituent of kidney brush-border membranes and is also present to a lesser degree in the brain and other tissues. It preferentially catalyzes cleavage at the amino group of hydrophobic residues of the B-chain of insulin as well as opioid peptides and other biologically active peptides. The enzyme is inhibited primarily by EDTA, phosphoramidon, and thiorphan and is reactivated by zinc. Neprilysin is identical to common acute lymphoblastic leukemia antigen (CALLA Antigen), an important marker in the diagnosis of human acute lymphocytic leukemia. There is no relationship with CALLA PLANT.
Broader concept
Entry terms
- Antigens, CD10
- Antigens, Leukemia, Common Acute Lymphoblastic
- Atriopeptidase
- CALLA Antigen
- CD10 Antigen
- CD10 Antigens
- Common Acute Lymphoblastic Leukemia Antigens
- Endopeptidase-24.11
- Enkephalinase
- Enkephalinase-24.11
- Enkephalin Dipeptidyl Carboxypeptidase
- Kidney-Brush-Border Neutral Proteinase
- Membrane Metallo-Endopeptidase
- Neutral Endopeptidase
- Neutral Endopeptidase 24.11
- Thermolysin-Like Metalloendopeptidase
- YGG-Forming Enzyme
Allowable Qualifier(s)
- administration & dosage (Qualifier)
- adverse effects (Qualifier)
- analysis (Qualifier)
- antagonists & inhibitors (Qualifier)
- biosynthesis (Qualifier)
- blood (Qualifier)
- cerebrospinal fluid (Qualifier)
- chemical synthesis (Qualifier)
- chemistry (Qualifier)
- classification (Qualifier)
- deficiency (Qualifier)
- drug effects (Qualifier)
- economics (Qualifier)
- genetics (Qualifier)
- history (Qualifier)
- immunology (Qualifier)
- isolation & purification (Qualifier)
- metabolism (Qualifier)
- pharmacokinetics (Qualifier)
- pharmacology (Qualifier)
- physiology (Qualifier)
- poisoning (Qualifier)
- radiation effects (Qualifier)
- standards (Qualifier)
- supply & distribution (Qualifier)
- therapeutic use (Qualifier)
- toxicity (Qualifier)
- ultrastructure (Qualifier)
- urine (Qualifier)
In other languages
-
French
-
Antigène CALLA
-
Antigène CD10
-
Antigènes de la leucémie aigüe lymphoblastique
-
Atriopeptidase
-
CD10
-
Endopeptidase neutre
-
Endopeptidase neutre 24.11
-
Enkephalin Dipeptidyl Carboxypeptidase
-
Enképhalinase
-
Métallo-endopeptidase membranaire
-
Protéinase neutre de la bordure en brosse rénale
-
Thermolysin-Like Metalloendopeptidase
-
YGG-Forming enzyme
URI
http://data.loterre.fr/ark:/67375/JVR-QNSPH4ZK-V
{{label}}
{{#each values }} {{! loop through ConceptPropertyValue objects }}
{{#if prefLabel }}
{{/if}}
{{/each}}
{{#if notation }}{{ notation }} {{/if}}{{ prefLabel }}
{{#ifDifferentLabelLang lang }} ({{ lang }}){{/ifDifferentLabelLang}}
{{#if vocabName }}
{{ vocabName }}
{{/if}}