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... > Enzymes and Coenzymes > Enzymes > Hydrolases > Esterases > Phosphoric Diester Hydrolases > Phospholipases > Phospholipases A > Phospholipases A2 > 1-Alkyl-2-acetylglycerophosphocholine Esterase
... > Enzymes and Coenzymes > Enzymes > Hydrolases > Esterases > Carboxylic Ester Hydrolases > Phospholipases > Phospholipases A > Phospholipases A2 > 1-Alkyl-2-acetylglycerophosphocholine Esterase

Preferred term

1-Alkyl-2-acetylglycerophosphocholine Esterase  

Type

  • mesh:Descriptor

Definition

  • A lipoprotein-associated PHOSPHOLIPASE A2 which modulates the action of PLATELET ACTIVATING FACTOR by hydrolyzing the SN-2 ester bond to yield the biologically inactive lyso-platelet-activating factor. It has specificity for phospholipid substrates with short-chain residues at the SN-2 position, but inactive against long-chain phospholipids. Deficiency in this enzyme is associated with many diseases including ASTHMA, and HYPERCHOLESTEROLEMIA.

Broader concept

Entry terms

  • Lipoprotein-Associated Phospholipase A(2)
  • Lipoprotein-Associated Phospholipase A2
  • Lp-PLA(2)
  • Lp-PLA2
  • PAF 2-Acetylhydrolase
  • PAF 2-Acylhydrolase
  • PAF Acetylhydrolase
  • PAF Acetylhydrolase II
  • Platelet-Activating Factor Hydrolase

Allowable Qualifier(s)

In other languages

  • 1-Alkyl-2-acetylglycerophosphocholine esterase

    French

  • Acétyl-hydrolase du facteur d'activation des plaquettes
  • Acétyl-hydrolase du facteur d'activation plaquettaire
  • Lipoprotein-associated phospholipase A2
  • Lp-PLA(2)
  • Lp-PLA2
  • PAF-acétylhydrolase
  • PAF-AH
  • Phospholipase A2 associée aux lipoprotéines
  • Platelet-activating factor hydrolase

URI

http://data.loterre.fr/ark:/67375/JVR-QPXCNVJB-B

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RDF/XML TURTLE JSON-LD Created 7/9/03, last modified 7/8/13