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... > Amino Acids, Peptides, and Proteins > Proteins > Blood Proteins > Serum Globulins > Immunoglobulins > Antibodies > Autoantibodies > Complement C3 Nephritic Factor
... > Amino Acids, Peptides, and Proteins > Proteins > Globulins > Serum Globulins > Immunoglobulins > Antibodies > Autoantibodies > Complement C3 Nephritic Factor
... > Amino Acids, Peptides, and Proteins > Proteins > Blood Proteins > Immunoproteins > Immunoglobulins > Antibodies > Autoantibodies > Complement C3 Nephritic Factor
... > Amino Acids, Peptides, and Proteins > Proteins > Blood Proteins > Immunoproteins > Complement System Proteins > Complement Inactivator Proteins > Complement C3 Nephritic Factor

Preferred term

Complement C3 Nephritic Factor  

Type

  • mesh:Descriptor

Definition

  • An IgG autoantibody against the ALTERNATIVE PATHWAY C3 CONVERTASE, found in serum of patients with MESANGIOCAPILLARY GLOMERULONEPHRITIS. The binding of this autoantibody to C3bBb stabilizes the enzyme thus reduces the actions of C3b inactivators (COMPLEMENT FACTOR H; COMPLEMENT FACTOR I). This abnormally stabilized enzyme induces a continuous COMPLEMENT ACTIVATION and generation of C3b thereby promoting the assembly of MEMBRANE ATTACK COMPLEX and cytolysis.

Broader concept

Entry terms

  • C 3 Nephritic Factor
  • C3 Nephritic Factor
  • Complement 3 Nephritic Factor

Allowable Qualifier(s)

Pharmacological Action(s)

In other languages

  • Facteur néphritique C3

    French

  • C3NeF
  • Facteur néphrétique C3
  • Facteur néphrétique C3-NeF
  • Facteur néphrétique C3NeF
  • Facteur néphritique C3-NeF
  • Facteur néphritique C3NeF

URI

http://data.loterre.fr/ark:/67375/JVR-R2G7RTL4-B

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RDF/XML TURTLE JSON-LD Created 5/20/77, last modified 7/30/09