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Immune System Diseases > Autoimmune Diseases > Polyendocrinopathies, Autoimmune
Endocrine System Diseases > Polyendocrinopathies, Autoimmune

Preferred term

Polyendocrinopathies, Autoimmune  

Type

  • mesh:Descriptor

Definition

  • Autoimmune diseases affecting multiple endocrine organs. Type I is characterized by childhood onset and chronic mucocutaneous candidiasis (CANDIDIASIS, CHRONIC MUCOCUTANEOUS), while type II exhibits any combination of adrenal insufficiency (ADDISON'S DISEASE), lymphocytic thyroiditis (THYROIDITIS, AUTOIMMUNE;), HYPOPARATHYROIDISM; and gonadal failure. In both types organ-specific ANTIBODIES against a variety of ENDOCRINE GLANDS have been detected. The type II syndrome differs from type I in that it is associated with HLA-A1 and B8 haplotypes, onset is usually in adulthood, and candidiasis is not present.

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URI

http://data.loterre.fr/ark:/67375/JVR-R60G0NHQ-D

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