Concept information
Preferred term
Amitriptyline
Type
-
mesh:Descriptor
Definition
- Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
Broader concept
Entry terms
- 17086-03-2 (pamoate (2:1))
- 1806D8D52K
- 1-Propanamine, 3-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-ylidene)-N,N-dimethyl-
- 26LUD4JO9K
- 30227-34-0 (maleate (1:1))
- 50-48-6 (Amitriptyline)
- 51052-95-0 (maleate (2:1))
- 51390-24-0 (maleate)
- 549-18-8 (HCl)
- 87987-25-5 (phosphate (1:1))
Allowable Qualifier(s)
- administration & dosage (Qualifier)
- adverse effects (Qualifier)
- agonists (Qualifier)
- analogs & derivatives (Qualifier)
- analysis (Qualifier)
- antagonists & inhibitors (Qualifier)
- blood (Qualifier)
- cerebrospinal fluid (Qualifier)
- chemical synthesis (Qualifier)
- chemistry (Qualifier)
- classification (Qualifier)
- economics (Qualifier)
- history (Qualifier)
- immunology (Qualifier)
- isolation & purification (Qualifier)
- metabolism (Qualifier)
- pharmacokinetics (Qualifier)
- pharmacology (Qualifier)
- poisoning (Qualifier)
- radiation effects (Qualifier)
- standards (Qualifier)
- supply & distribution (Qualifier)
- therapeutic use (Qualifier)
- toxicity (Qualifier)
- urine (Qualifier)
Pharmacological Action(s)
In other languages
-
French
-
1-Propanamine, 3-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-ylidene)-N,N-dimethyl-
-
17086-03-2 (pamoate (2:1))
-
1806D8D52K
-
26LUD4JO9K
-
30227-34-0 (maleate (1:1))
-
50-48-6 (Amitriptyline)
-
51052-95-0 (maleate (2:1))
-
51390-24-0 (maleate)
-
549-18-8 (HCl)
-
87987-25-5 (phosphate (1:1))
URI
http://data.loterre.fr/ark:/67375/JVR-R71MKQ38-X
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