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Concept information

... > Lipids > Fatty Acids > Fatty Acids, Unsaturated > Eicosanoids > Arachidonic Acids > Hydroxyeicosatetraenoic Acids > 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid
... > Biological Factors > Inflammation Mediators > Autacoids > Eicosanoids > Arachidonic Acids > Hydroxyeicosatetraenoic Acids > 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid
... > Lipids > Fatty Acids > Fatty Acids, Unsaturated > Fatty Acids, Essential > Arachidonic Acids > Hydroxyeicosatetraenoic Acids > 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid

Preferred term

12-Hydroxy-5,8,10,14-eicosatetraenoic Acid  

Type

  • mesh:Descriptor

Definition

  • A lipoxygenase metabolite of ARACHIDONIC ACID. It is a highly selective ligand used to label mu-opioid receptors in both membranes and tissue sections. The 12-S-HETE analog has been reported to augment tumor cell metastatic potential through activation of protein kinase C. (J Pharmacol Exp Ther 1995; 274(3):1545-51; J Natl Cancer Inst 1994; 86(15):1145-51)

Broader concept

Entry terms

  • 12-HETE
  • 59985-28-3

Allowable Qualifier(s)

In other languages

URI

http://data.loterre.fr/ark:/67375/JVR-R7P19PP9-G

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RDF/XML TURTLE JSON-LD Created 6/10/96, last modified 6/22/15