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... > Nucleic Acids, Nucleotides, and Nucleosides > Nucleic Acids > RNA > RNA, Untranslated > RNA, Small Untranslated > MicroRNAs
Nucleic Acids, Nucleotides, and Nucleosides > Nucleic Acids > RNA > RNA, Antisense > MicroRNAs
... > Chemical Actions and Uses > Specialty Uses of Chemicals > Laboratory Chemicals > Molecular Probes > Nucleic Acid Probes > Antisense Elements (Genetics) > RNA, Antisense > MicroRNAs
... > Chemical Actions and Uses > Pharmacologic Actions > Diagnostic Uses of Chemicals > Molecular Probes > Nucleic Acid Probes > Antisense Elements (Genetics) > RNA, Antisense > MicroRNAs
... > Nucleic Acids, Nucleotides, and Nucleosides > Nucleic Acids > Nucleic Acid Probes > Antisense Elements (Genetics) > RNA, Antisense > MicroRNAs

Preferred term

MicroRNAs  

Type

  • mesh:Descriptor

Definition

  • Small double-stranded, non-protein coding RNAs, 21-25 nucleotides in length generated from single-stranded microRNA gene transcripts by the same RIBONUCLEASE III, Dicer, that produces small interfering RNAs (RNA, SMALL INTERFERING). They become part of the RNA-INDUCED SILENCING COMPLEX and repress the translation (TRANSLATION, GENETIC) of target RNA by binding to homologous 3'UTR region as an imperfect match. The small temporal RNAs (stRNAs), let-7 and lin-4, from C. elegans, are the first 2 miRNAs discovered, and are from a class of miRNAs involved in developmental timing. The RNA transcript of the miRNA genes prior to processing to pre-miRNA. A class of microRNAs that regulate developmental timing. Precursors to miRNA generated from pri-miRNA. They are exported from the nucleus where they are further processed by Dicer RNase to generate mature miRNA.

Broader concept

Narrower concepts

Related concepts

Entry terms

  • Micro RNA
  • MicroRNA
  • miRNA
  • miRNAs

Allowable Qualifier(s)

In other languages

URI

http://data.loterre.fr/ark:/67375/JVR-RPP5P6HF-L

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RDF/XML TURTLE JSON-LD Created 7/3/02, last modified 7/9/13