Concept information
...
Peptides
Intracellular Signaling Peptides and Proteins
Guanylate Cyclase
Receptors, Guanylate Cyclase-Coupled
Preferred term
Receptors, Enterotoxin
Type
-
mesh:Descriptor
Definition
- Guanylate cyclase-coupled receptors that bind bacterial ENTEROTOXINS, as well as the endogenous peptides guanylin and uroguanylin. Ligand binding stimulates production of CYCLIC GMP by EPITHELIAL CELLS of the intestinal lumen, altering barrier permeability and mucus secretion. Mutations in the gene (GUCY2C) encoding this receptor are associated with some cases of hereditary diarrhea (Diarrhea 6) and MECONIUM ILEUS.
Broader concept
Entry terms
- Enterotoxin-Guanylin Receptor
- Enterotoxin-Guanylin Receptors
- Enterotoxin Receptor
- Enterotoxin Receptors
- GC-C Receptor
- GC-C Receptors
- Guanyl Cyclase-C Receptor
- Guanyl Cyclase-C Receptors
- Guanylin-Uroguanylin Receptor
- Guanylin-Uroguanylin Receptors
- Guanylyl Cyclase C
- Heat-Stable Enterotoxin Receptor
- Heat-Stable Enterotoxin Receptors
- Receptor, Enterotoxin
- Receptor, Guanyl Cyclase-C
- Receptors, Guanyl Cyclase-C
Allowable Qualifier(s)
- administration & dosage (Qualifier)
- analysis (Qualifier)
- antagonists & inhibitors (Qualifier)
- biosynthesis (Qualifier)
- blood (Qualifier)
- chemistry (Qualifier)
- classification (Qualifier)
- deficiency (Qualifier)
- drug effects (Qualifier)
- genetics (Qualifier)
- history (Qualifier)
- immunology (Qualifier)
- isolation & purification (Qualifier)
- metabolism (Qualifier)
- physiology (Qualifier)
- radiation effects (Qualifier)
- therapeutic use (Qualifier)
- ultrastructure (Qualifier)
In other languages
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French
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Récepteurs à activité guanylate cyclase-C
-
Récepteurs à activité guanylyl cyclase-C
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Récepteurs de la guanyline et de l'uroguanyline
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Récepteurs des entérotoxines et de la guanyline
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Récepteurs des entérotoxines thermostables
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Récepteurs GC-C
URI
http://data.loterre.fr/ark:/67375/JVR-RT40K0PH-K
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