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... > Chemical Actions and Uses > Specialty Uses of Chemicals > Laboratory Chemicals > Molecular Probes > Nucleic Acid Probes > DNA Probes
... > Chemical Actions and Uses > Pharmacologic Actions > Diagnostic Uses of Chemicals > Molecular Probes > Nucleic Acid Probes > DNA Probes
Nucleic Acids, Nucleotides, and Nucleosides > Nucleic Acids > Nucleic Acid Probes > DNA Probes

Preferred term

DNA Probes  

Type

  • mesh:Descriptor

Definition

  • Species- or subspecies-specific DNA (including COMPLEMENTARY DNA; conserved genes, whole chromosomes, or whole genomes) used in hybridization studies in order to identify microorganisms, to measure DNA-DNA homologies, to group subspecies, etc. The DNA probe hybridizes with a specific mRNA, if present. Conventional techniques used for testing for the hybridization product include dot blot assays, Southern blot assays, and DNA:RNA hybrid-specific antibody tests. Conventional labels for the DNA probe include the radioisotope labels 32P and 125I and the chemical label biotin. The use of DNA probes provides a specific, sensitive, rapid, and inexpensive replacement for cell culture techniques for diagnosing infections.

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Entry terms

  • DNA Hybridization Probe
  • DNA Hybridization Probes
  • DNA Probe

Allowable Qualifier(s)

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URI

http://data.loterre.fr/ark:/67375/JVR-RZ5QQG50-R

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