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Concept information

Biological Factors > Intercellular Signaling Peptides and Proteins > Angiogenic Proteins > Angiopoietin-like Proteins > Angiopoietin-Like Protein 4
... > Amino Acids, Peptides, and Proteins > Peptides > Intercellular Signaling Peptides and Proteins > Angiogenic Proteins > Angiopoietin-like Proteins > Angiopoietin-Like Protein 4
... > Amino Acids, Peptides, and Proteins > Proteins > Intercellular Signaling Peptides and Proteins > Angiogenic Proteins > Angiopoietin-like Proteins > Angiopoietin-Like Protein 4

Preferred term

Angiopoietin-Like Protein 4  

Type

  • mesh:Descriptor

Definition

  • A secreted angiopoietin-like protein expressed under hypoxic conditions by ENDOTHELIAL CELLS. It inhibits cell proliferation, cell migration, and tubule formation; the inactive form accumulates in the endothelial EXTRACELLULAR MATRIX, reducing vascular leakage. ANGPTL4 has direct roles in regulating glucose and lipid metabolism, as well as INSULIN SENSITIVITY, and may also function as a regulator of angiogenesis and tumorigenesis.

Broader concept

Synonym(s)

  • Angiopoietin-related Protein 4
  • ANGPTL4 Protein

Allowable Qualifier(s)

In other languages

URI

http://data.loterre.fr/ark:/67375/JVR-SK5W2JCF-L

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RDF/XML TURTLE JSON-LD Created 7/11/17, last modified 6/27/21