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... > Amino Acids, Peptides, and Proteins > Peptides > Intracellular Signaling Peptides and Proteins > Adaptor Proteins, Signal Transducing > Suppressor of Cytokine Signaling Proteins > Suppressor of Cytokine Signaling 1 Protein
... > Amino Acids, Peptides, and Proteins > Proteins > Intracellular Signaling Peptides and Proteins > Adaptor Proteins, Signal Transducing > Suppressor of Cytokine Signaling Proteins > Suppressor of Cytokine Signaling 1 Protein
... > Amino Acids, Peptides, and Proteins > Proteins > Carrier Proteins > Adaptor Proteins, Signal Transducing > Suppressor of Cytokine Signaling Proteins > Suppressor of Cytokine Signaling 1 Protein

Preferred term

Suppressor of Cytokine Signaling 1 Protein  

Type

  • mesh:Descriptor

Definition

  • A suppressor of cytokine signaling protein that consists of an N-terminal kinase-inhibitory region, a central SH2 DOMAIN, a characteristic C-terminal SOCS box (a 40-amino acid motif, which functions to recruit E3 UBIQUITIN-PROTEIN LIGASE COMPLEXES). SOCS1 functions as a negative regulator of CYTOKINES that signal through the JANUS KINASES-STAT 3 TRANSCRIPTION FACTOR (JAK/STAT3) pathway by inhibiting the activity of JANUS KINASES.

Broader concept

Entry terms

  • SOCS1 Protein
  • Suppressor of Cytokine Signaling Protein 1 -

Allowable Qualifier(s)

In other languages

URI

http://data.loterre.fr/ark:/67375/JVR-SWV5Q6G3-S

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RDF/XML TURTLE JSON-LD Created 7/8/16, last modified 4/15/16