Concept information
Preferred term
Nitric Oxide
Type
-
mesh:Descriptor
Definition
- A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
Broader concept
Entry terms
- 10102-43-9 (Nitric Oxide)
- 31C4KY9ESH
- Endogenous Nitrate Vasodilator
- Mononitrogen Monoxide
- Nitric Oxide, Endothelium-Derived
- Nitrogen Monoxide
- Nitrogen oxide (NO)
Allowable Qualifier(s)
- administration & dosage (Qualifier)
- adverse effects (Qualifier)
- agonists (Qualifier)
- analogs & derivatives (Qualifier)
- analysis (Qualifier)
- antagonists & inhibitors (Qualifier)
- biosynthesis (Qualifier)
- blood (Qualifier)
- cerebrospinal fluid (Qualifier)
- chemical synthesis (Qualifier)
- chemistry (Qualifier)
- classification (Qualifier)
- deficiency (Qualifier)
- economics (Qualifier)
- genetics (Qualifier)
- history (Qualifier)
- immunology (Qualifier)
- isolation & purification (Qualifier)
- metabolism (Qualifier)
- pharmacokinetics (Qualifier)
- pharmacology (Qualifier)
- physiology (Qualifier)
- poisoning (Qualifier)
- radiation effects (Qualifier)
- standards (Qualifier)
- supply & distribution (Qualifier)
- therapeutic use (Qualifier)
- toxicity (Qualifier)
- urine (Qualifier)
Pharmacological Action(s)
In other languages
-
French
-
10102-43-9 (Nitric Oxide)
-
31C4KY9ESH
-
Monoxyde d'azote dérivé de l'endothélium
-
Nitrogen oxide (NO)
-
Oxyde azotique
-
Oxyde nitrique
URI
http://data.loterre.fr/ark:/67375/JVR-T12KJKC0-0
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