Skip to main content

Medical Subject Headings (thesaurus)

Search from vocabulary

align
annotate
download

Concept information

Biological Factors > Toxins, Biological > Mycotoxins > Aflatoxins > Aflatoxin M1
... > Heterocyclic Compounds > Heterocyclic Compounds, Fused-Ring > Heterocyclic Compounds, 2-Ring > Benzopyrans > Aflatoxins > Aflatoxin M1
... > Heterocyclic Compounds > Heterocyclic Compounds, 1-Ring > Pyrans > Benzopyrans > Aflatoxins > Aflatoxin M1

Preferred term

Aflatoxin M1  

Type

  • mesh:Descriptor

Definition

  • A 4-hydroxylated metabolite of AFLATOXIN B1, one of the MYCOTOXINS from ASPERGILLUS tainted food. It is associated with LIVER damage and cancer resulting from its P450 activation to the epoxide which alkylates DNA. Toxicity depends on the balance of liver enzymes that activate it (CYTOCHROME P-450) and others that detoxify it (GLUTATHIONE S TRANSFERASE) (Pharmac Ther 50.443 1991). Primates & rat are sensitive while mouse and hamster are tolerant (Canc Res 29.236 1969).

Broader concept

Entry terms

  • 25325-49-9 (cis(+-)-isomer)
  • 4-Hydroxyaflatoxin B1
  • 6795-23-9
  • Aflatoxin M(1)
  • Cyclopenta(c)furo(3',2':4,5)furo(2,3-h)(1)benzopyran-1,11-dione, 2,3,6a,9a-tetrahydro-9a-hydroxy-4-methoxy-, (6aR-cis)-

Allowable Qualifier(s)

Pharmacological Action(s)

In other languages

  • Aflatoxine M1

    French

  • 25325-49-9 (cis(+-)-isomer)
  • 4-Hydroxy-aflatoxine B1
  • 6795-23-9
  • Cyclopenta(c)furo(3',2':4,5)furo(2,3-h)(1)benzopyran-1,11-dione, 2,3,6a,9a-tetrahydro-9a-hydroxy-4-methoxy-, (6aR-cis)-

URI

http://data.loterre.fr/ark:/67375/JVR-T72WT1C3-T

Download this concept:

RDF/XML TURTLE JSON-LD Created 1/25/91, last modified 5/27/20