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Concept information

Genetic Phenomena > Genetic Variation > Mutation > Codon, Nonsense
... > Genetic Phenomena > Genetic Structures > Genetic Code > Codon > Codon, Terminator > Codon, Nonsense
... > Genetic Phenomena > Genetic Structures > Genome > Genome Components > Genes > Gene Components > Codon > Codon, Terminator > Codon, Nonsense
... > Nucleic Acids, Nucleotides, and Nucleosides > Nucleic Acids > RNA > RNA, Messenger > Codon > Codon, Terminator > Codon, Nonsense

Preferred term

Codon, Nonsense  

Type

  • mesh:Descriptor

Definition

  • An amino acid-specifying codon that has been converted to a stop codon (CODON, TERMINATOR) by mutation. Its occurance is abnormal causing premature termination of protein translation and results in production of truncated and non-functional proteins. A nonsense mutation is one that converts an amino acid-specific codon to a stop codon. A mutation that converts a sense codon (CODON) into a stop codon (CODON, TERMINATOR) or an unassigned codon and leads to the formation of truncated proteins. A codon that is not assigned to an amino acid and is not a stop codon (CODON, TERMINATOR). Although they may lead to premature termination of translation, unassigned codons do not bind translation release factors (PEPTIDE TERMINATION FACTORS), as do stop codons.

Broader concept

Entry terms

  • Codon, Termination, Premature
  • Nonsense Codon
  • Premature Stop Codon
  • Premature Termination Codon

Allowable Qualifier(s)

In other languages

  • Codon non-sens

    French

  • Codon de terminaison prématuré
  • Codon stop prématuré

URI

http://data.loterre.fr/ark:/67375/JVR-T739CM7H-2

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RDF/XML TURTLE JSON-LD Created 6/3/94, last modified 7/9/13