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... > Amino Acids, Peptides, and Proteins > Proteins > Blood Proteins > Immunoproteins > Complement System Proteins > Complement Activating Enzymes > Complement C3-C5 Convertases > Complement C3-C5 Convertases, Alternative Pathway > Complement C3 Convertase, Alternative Pathway
... > Enzymes and Coenzymes > Enzymes > Hydrolases > Complement Activating Enzymes > Complement C3-C5 Convertases > Complement C3-C5 Convertases, Alternative Pathway > Complement C3 Convertase, Alternative Pathway

Preferred term

Complement C3 Convertase, Alternative Pathway  

Type

  • mesh:Descriptor

Definition

  • A serine protease that is the complex of COMPLEMENT C3B and COMPLEMENT FACTOR BB. It cleaves multiple COMPLEMENT C3 into COMPLEMENT C3A (anaphylatoxin) and COMPLEMENT C3B in the ALTERNATIVE COMPLEMENT ACTIVATION PATHWAY. Cobra venom factor (CVF) is a COMPLEMENT C3B analog. With Bb, CVF forms the CVFBb complex, a COMPLEMENT C3 convertase with a half-life of 7 h at body temperature as compared to 1.5 min for the C3bBb complex. The cobra venom-derived enzyme causes continuous COMPLEMENT ACTIVATION and depletion of downstream complement components.

Broader concept

Entry terms

  • Alternative Pathway C3 Convertase
  • C3 Convertase, Alternative Pathway
  • C3 Convertase (C3bBb)
  • Complement 3b-Associated Factor B-fragment Bb
  • Complement 3 Convertase, Alternative Pathway

Allowable Qualifier(s)

Pharmacological Action(s)

In other languages

URI

http://data.loterre.fr/ark:/67375/JVR-T875T2L4-K

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RDF/XML TURTLE JSON-LD Created 6/30/05, last modified 7/5/06