Concept information
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Membrane Proteins
Receptors, Cell Surface
Receptors, Immunologic
Platelet Membrane Glycoproteins
[show all 6 paths]
Preferred term
Integrin alpha6beta1
Type
-
mesh:Descriptor
Definition
- A cell surface receptor mediating cell adhesion to the EXTRACELLULAR MATRIX and to other cells via binding to LAMININ. It is involved in cell migration, embryonic development, leukocyte activation and tumor cell invasiveness. Integrin alpha6beta1 is the major laminin receptor on PLATELETS; LEUKOCYTES; and many EPITHELIAL CELLS, and ligand binding may activate a number of signal transduction pathways. Alternative splicing of the cytoplasmic domain of the alpha6 subunit (INTEGRIN ALPHA6) results in the formation of A and B isoforms of the heterodimer, which are expressed in a tissue-specific manner.
Synonym(s)
- alpha 6 beta 1 Integrin
- alpha6beta1 Integrin
- CD49f-CD29
- Integrin alpha(6)beta(1)
- Platelet Glycoprotein I'c-IIa
- VLA-6
Allowable Qualifier(s)
- administration & dosage (Qualifier)
- agonists (Qualifier)
- analysis (Qualifier)
- antagonists & inhibitors (Qualifier)
- biosynthesis (Qualifier)
- blood (Qualifier)
- chemistry (Qualifier)
- classification (Qualifier)
- deficiency (Qualifier)
- drug effects (Qualifier)
- genetics (Qualifier)
- history (Qualifier)
- immunology (Qualifier)
- isolation & purification (Qualifier)
- metabolism (Qualifier)
- physiology (Qualifier)
- radiation effects (Qualifier)
- therapeutic use (Qualifier)
- ultrastructure (Qualifier)
- [show all 19 values]
In other languages
-
French
-
CD49f-CD29
-
Intégrine alpha-6-bêta-1
-
Intégrine alpha6 bêta1
-
VLA-6
URI
http://data.loterre.fr/ark:/67375/JVR-THH4GV7X-H
Equivalent concepts
id.nlm.nih.gov
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