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Concept information

Organic Chemicals > Hydrocarbons > Terpenes > Diterpenes > Aphidicolin

Preferred term

Aphidicolin  

Type

  • mesh:Descriptor

Definition

  • An antiviral antibiotic produced by Cephalosporium aphidicola and other fungi. It inhibits the growth of eukaryotic cells and certain animal viruses by selectively inhibiting the cellular replication of DNA polymerase II or the viral-induced DNA polymerases. The drug may be useful for controlling excessive cell proliferation in patients with cancer, psoriasis or other dermatitis with little or no adverse effect upon non-multiplying cells.

Broader concept

Entry terms

  • 38966-21-1
  • 52645-92-8 ((3-S-(3alpha,4beta,4abeta,6aalpha,8alpha,9alpha,11aalpha,11balpha))-isomer)
  • 9,15-Cyclo-C,18-dinor-14,15-secoandrostane-4,17-dimethanol, 3,17-dihydroxy-4-methyl-, (3alpha,4alpha,5alpha,17alpha)-

Allowable Qualifier(s)

Pharmacological Action(s)

In other languages

  • Aphidicoline

    French

  • 38966-21-1
  • 52645-92-8 ((3-S-(3alpha,4beta,4abeta,6aalpha,8alpha,9alpha,11aalpha,11balpha))-isomer)
  • 9,15-Cyclo-C,18-dinor-14,15-secoandrostane-4,17-dimethanol, 3,17-dihydroxy-4-methyl-, (3alpha,4alpha,5alpha,17alpha)-

URI

http://data.loterre.fr/ark:/67375/JVR-V419LWCW-L

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