: MeSH: Tissue Distribution

Metabolism > Pharmacokinetics > Tissue Distribution

Physiological Phenomena > Pharmacological and Toxicological Phenomena > Pharmacokinetics > Tissue Distribution

Tissue Distribution

Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.

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