: MeSH: Giant Cells, Langhans

Cells > Connective Tissue Cells > Macrophages > Giant Cells, Langhans

Hemic and Immune Systems > Immune System > Mononuclear Phagocyte System > Macrophages > Giant Cells, Langhans

Cells > Phagocytes > Macrophages > Giant Cells, Langhans

Hemic and Immune Systems > Immune System > Phagocytes > Macrophages > Giant Cells, Langhans

Cells > Myeloid Cells > Macrophages > Giant Cells, Langhans

Cells > Giant Cells > Giant Cells, Langhans

Giant Cells, Langhans

Multinucleated cells (fused macrophages) seen in granulomatous inflammations such as tuberculosis, syphilis, sarcoidosis, and deep fungal infections. They resemble foreign-body giant cells (GIANT CELLS, FOREIGN BODY) but Langhans giant cells contain less chromatin and their nuclei are arranged peripherally in a horseshoe-shaped pattern. Langhans giant cells occur frequently in delayed hypersensitivity.

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