Skip to main content

Medical Subject Headings (thesaurus)

Search from vocabulary

align
annotate
download

Concept information

Amino Acids, Peptides, and Proteins > Proteins > DNA-Binding Proteins > Kruppel-Like Transcription Factors > Promyelocytic Leukemia Zinc Finger Protein
Amino Acids, Peptides, and Proteins > Proteins > Transcription Factors > Kruppel-Like Transcription Factors > Promyelocytic Leukemia Zinc Finger Protein

Preferred term

Promyelocytic Leukemia Zinc Finger Protein  

Type

  • mesh:Descriptor

Definition

  • A Kruppel-type transcription factor consisting of an N-terminal BTB DOMAIN and nine CYS2-HIS2 ZINC FINGERS. It localizes to the nucleus and regulates cell cycle progression and gene expression for tissue development and homeostasis; it may also function as an epigenetic regulator through its interactions with HISTONE DEACETYLASE. Genetic rearrangements involving the ZBTB16 gene are associated with ACUTE PROMYELOCYTIC LEUKEMIA.

Broader concept

Entry terms

  • PLZF Protein
  • Promyelocytic Leukaemia Zinc Finger Protein
  • ZBTB16 Protein
  • Zinc Finger and BTB Domain Containing 16 Protein

Allowable Qualifier(s)

In other languages

URI

http://data.loterre.fr/ark:/67375/JVR-VKZ967WZ-J

Download this concept:

RDF/XML TURTLE JSON-LD Created 7/11/17, last modified 5/21/18