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... > Amino Acids, Peptides, and Proteins > Proteins > Glycoproteins > Membrane Glycoproteins > Cell Adhesion Molecules > Cell Adhesion Molecules, Neuronal > Neural Cell Adhesion Molecules > Neural Cell Adhesion Molecule L1
... > Carbohydrates > Glycoconjugates > Glycoproteins > Membrane Glycoproteins > Cell Adhesion Molecules > Cell Adhesion Molecules, Neuronal > Neural Cell Adhesion Molecules > Neural Cell Adhesion Molecule L1
... > Amino Acids, Peptides, and Proteins > Proteins > Membrane Proteins > Membrane Glycoproteins > Cell Adhesion Molecules > Cell Adhesion Molecules, Neuronal > Neural Cell Adhesion Molecules > Neural Cell Adhesion Molecule L1
... > Biological Factors > Antigens > Antigens, Surface > Cell Adhesion Molecules > Cell Adhesion Molecules, Neuronal > Neural Cell Adhesion Molecules > Neural Cell Adhesion Molecule L1

Preferred term

Neural Cell Adhesion Molecule L1  

Type

  • mesh:Descriptor

Definition

  • A member of the immunoglobulin superfamily of neuronal cell adhesion molecules that is required for proper nervous system development. Neural cell adhesion molecule L1 consists of six Ig domains, five fibronectin domains, a transmembrane region and an intracellular domain. Two splicing variants are known: a neuronal form that contains a four-amino acid RSLE sequence in the cytoplasmic domain, and a non-neuronal form that lacks the RSLE sequence. Mutations in the L1 gene result in L1 disease. Neural cell adhesion molecule L1 is predominantly expressed during development in neurons and Schwann cells; involved in cell adhesion, neuronal migration, axonal growth and pathfinding, and myelination.

Broader concept

Entry terms

  • CALL Protein
  • CamL1 Gene Product
  • Cell Adhesion Molecule L1
  • Cell Surface Glycoprotein L1
  • F11 Glycoprotein
  • L1CAM
  • L1 Cell Adhesion Molecule
  • Nerve Growth Factor-Inducible Large External Glycoprotein
  • Neural Adhesion Molecule L1
  • NGF-Inducible Glycoprotein
  • NILE Glycoprotein
  • NILE Protein

Allowable Qualifier(s)

In other languages

  • Molécule d'adhérence cellulaire neurale L-1

    French

  • Glycoprotéine de surface cellulaire L1
  • Glycoprotéine F11
  • Glycoprotéine NILE
  • L1CAM
  • Molécule d'adhérence cellulaire L1 neurale
  • Molécule d'adhérence cellulaire L1-CAM
  • Molécule d'adhésion cellulaire L1 neurale
  • Molécule d'adhésion cellulaire L1-CAM
  • Molécule d'adhésion cellulaire neurale L-1
  • Molécule L1 d'adhérence cellulaire neurale
  • Molécule L1 d'adhésion cellulaire neurale
  • N-CAM-L1
  • NCAM L1
  • Protéine CALL
  • Protéine CAML1
  • Protéine NILE

URI

http://data.loterre.fr/ark:/67375/JVR-VVTH1SBN-Q

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RDF/XML TURTLE JSON-LD Created 7/3/02, last modified 7/9/13