Concept information
Preferred term
Dextromethorphan
Type
-
mesh:Descriptor
Definition
- Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist (RECEPTORS, N-METHYL-D-ASPARTATE) and acts as a non-competitive channel blocker. It is one of the widely used ANTITUSSIVES, and is also used to study the involvement of glutamate receptors in neurotoxicity.
Broader concept
Entry terms
- 125-68-8 (HBr, cpd w/o isomeric designation)
- 125-69-9 (HBr)
- 125-71-3 (Dextromethorphan)
- 18609-21-7 (HCl)
- 351KFH969D
- 510-53-2 ((+-)-isomer)
- 6031-86-3 (HBr, (+-)-isomer)
- 6700-34-1 (HBr, mono-hydrate)
- 7355X3ROTS
- 7ZZ22K9QE6
- 8YB8F78WM1
- 9D2RTI9KYH
- d-Methorphan
- Morphinan, 3-methoxy-17-methyl-, (9alpha,13alpha,14alpha)-
Allowable Qualifier(s)
- administration & dosage (Qualifier)
- adverse effects (Qualifier)
- agonists (Qualifier)
- analogs & derivatives (Qualifier)
- analysis (Qualifier)
- antagonists & inhibitors (Qualifier)
- blood (Qualifier)
- cerebrospinal fluid (Qualifier)
- chemical synthesis (Qualifier)
- chemistry (Qualifier)
- classification (Qualifier)
- economics (Qualifier)
- history (Qualifier)
- immunology (Qualifier)
- isolation & purification (Qualifier)
- metabolism (Qualifier)
- pharmacokinetics (Qualifier)
- pharmacology (Qualifier)
- poisoning (Qualifier)
- radiation effects (Qualifier)
- standards (Qualifier)
- supply & distribution (Qualifier)
- therapeutic use (Qualifier)
- toxicity (Qualifier)
- urine (Qualifier)
Pharmacological Action(s)
In other languages
-
French
-
125-68-8 (HBr, cpd w/o isomeric designation)
-
125-69-9 (HBr)
-
125-71-3 (Dextromethorphan)
-
18609-21-7 (HCl)
-
351KFH969D
-
510-53-2 ((+-)-isomer)
-
6031-86-3 (HBr, (+-)-isomer)
-
6700-34-1 (HBr, mono-hydrate)
-
7355X3ROTS
-
7ZZ22K9QE6
-
8YB8F78WM1
-
9D2RTI9KYH
-
Morphinan, 3-methoxy-17-methyl-, (9alpha,13alpha,14alpha)-
URI
http://data.loterre.fr/ark:/67375/JVR-W0DQVCD4-F
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