: MeSH: Neurofibroma

Nervous System Diseases > Nervous System Neoplasms > Peripheral Nervous System Neoplasms > Nerve Sheath Neoplasms > Neurofibroma

... > Neoplasms by Site > Nervous System Neoplasms > Peripheral Nervous System Neoplasms > Nerve Sheath Neoplasms > Neurofibroma

... > Neuromuscular Diseases > Peripheral Nervous System Diseases > Peripheral Nervous System Neoplasms > Nerve Sheath Neoplasms > Neurofibroma

Neoplasms > Neoplasms by Histologic Type > Neoplasms, Nerve Tissue > Nerve Sheath Neoplasms > Neurofibroma

Neurofibroma

A moderately firm, benign, encapsulated tumor resulting from proliferation of SCHWANN CELLS and FIBROBLASTS that includes portions of nerve fibers. The tumors usually develop along peripheral or cranial nerves and are a central feature of NEUROFIBROMATOSIS 1, where they may occur intracranially or involve spinal roots. Pathologic features include fusiform enlargement of the involved nerve. Microscopic examination reveals a disorganized and loose cellular pattern with elongated nuclei intermixed with fibrous strands. (From Adams et al., Principles of Neurology, 6th ed, p1016)

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