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... > Amino Acids, Peptides, and Proteins > Proteins > Glycoproteins > Membrane Glycoproteins > ATP-Binding Cassette Transporters > ATP Binding Cassette Transporter, Subfamily B
... > Carbohydrates > Glycoconjugates > Glycoproteins > Membrane Glycoproteins > ATP-Binding Cassette Transporters > ATP Binding Cassette Transporter, Subfamily B
... > Amino Acids, Peptides, and Proteins > Proteins > Membrane Proteins > Membrane Glycoproteins > ATP-Binding Cassette Transporters > ATP Binding Cassette Transporter, Subfamily B
... > Amino Acids, Peptides, and Proteins > Proteins > Membrane Proteins > Membrane Transport Proteins > ATP-Binding Cassette Transporters > ATP Binding Cassette Transporter, Subfamily B
... > Amino Acids, Peptides, and Proteins > Proteins > Carrier Proteins > Membrane Transport Proteins > ATP-Binding Cassette Transporters > ATP Binding Cassette Transporter, Subfamily B
... > Amino Acids, Peptides, and Proteins > Proteins > Membrane Proteins > Membrane Transport Proteins > Ion Pumps > Anion Transport Proteins > Organic Anion Transporters > Organic Anion Transporters, ATP-Dependent > ATP Binding Cassette Transporter, Subfamily B
... > Amino Acids, Peptides, and Proteins > Proteins > Carrier Proteins > Membrane Transport Proteins > Ion Pumps > Anion Transport Proteins > Organic Anion Transporters > Organic Anion Transporters, ATP-Dependent > ATP Binding Cassette Transporter, Subfamily B

Preferred term

ATP Binding Cassette Transporter, Subfamily B  

Type

  • mesh:Descriptor

Definition

  • A subfamily of transmembrane proteins from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS that are closely related in sequence to ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1. When overexpressed, they function as ATP-dependent efflux pumps able to extrude lipophilic drugs (especially ANTINEOPLASTIC AGENTS) from cells, causing multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.

Broader concept

Narrower concepts

Related concepts

Entry terms

  • ATP-Binding Cassette, Sub-Family B Proteins
  • ATP Binding Cassette Transporter, Sub-Family B
  • Multidrug Resistance Proteins
  • P-Glycoproteins

Allowable Qualifier(s)

In other languages

  • Sous-famille B de transporteurs à cassette liant l'ATP

    French

  • Glycoprotéines P
  • Protéines de résistance multidrogue
  • Protéines de résistance multiple aux drogues
  • Protéines de résistance multiple aux médicaments
  • Sous-famille B de protéines à cassette de liaison à l'ATP
  • Sous-famille B de protéines à cassette liant l'ATP
  • Sous-famille B de transporteurs à cassette de liaison à l'ATP

URI

http://data.loterre.fr/ark:/67375/JVR-WDNTVV9S-2

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RDF/XML TURTLE JSON-LD Created 1/25/94, last modified 4/29/19