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Cells > Neurons > Neuropil > Neuropil Threads
Nervous System > Neurons > Neuropil > Neuropil Threads
Cells > Neuroglia > Neuropil > Neuropil Threads
Nervous System > Neuroglia > Neuropil > Neuropil Threads
... > Cells > Cellular Structures > Intracellular Space > Cytoplasm > Cytoplasmic Structures > Cytoskeleton > Microtubules > Neuropil Threads
... > Fluids and Secretions > Body Fluids > Body Fluid Compartments > Intracellular Space > Cytoplasm > Cytoplasmic Structures > Cytoskeleton > Microtubules > Neuropil Threads
... > Tissues > Body Fluid Compartments > Intracellular Space > Cytoplasm > Cytoplasmic Structures > Cytoskeleton > Microtubules > Neuropil Threads

Preferred term

Neuropil Threads  

Type

  • mesh:Descriptor

Definition

  • Abnormal structures located chiefly in distal dendrites and, along with NEUROFIBRILLARY TANGLES and SENILE PLAQUES, constitute the three morphological hallmarks of ALZHEIMER DISEASE. Neuropil threads are made up of straight and paired helical filaments which consist of abnormally phosphorylated microtubule-associated tau proteins. It has been suggested that the threads have a major role in the cognitive impairment seen in Alzheimer disease.

Broader concept

Allowable Qualifier(s)

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URI

http://data.loterre.fr/ark:/67375/JVR-WJVH5LGV-6

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RDF/XML TURTLE JSON-LD Created 6/20/97, last modified 9/27/12