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Amino Acids, Peptides, and Proteins > Proteins > Pregnancy Proteins > Pregnancy-Associated Plasma Protein-A
... > Enzymes and Coenzymes > Enzymes > Hydrolases > Peptide Hydrolases > Endopeptidases > Metalloendopeptidases > Pregnancy-Associated Plasma Protein-A
... > Enzymes and Coenzymes > Enzymes > Hydrolases > Peptide Hydrolases > Metalloproteases > Metalloendopeptidases > Pregnancy-Associated Plasma Protein-A

Preferred term

Pregnancy-Associated Plasma Protein-A  

Type

  • mesh:Descriptor

Definition

  • A product of the PLACENTA, and DECIDUA, secreted into the maternal circulation during PREGNANCY. It has been identified as an IGF binding protein (IGFBP)-4 protease that proteolyzes IGFBP-4 and thus increases IGF bioavailability. It is found also in human FIBROBLASTS, ovarian FOLLICULAR FLUID, and GRANULOSA CELLS. The enzyme is a heterotetramer of about 500-kDa.

Broader concept

Entry terms

  • IGFBP-4 Metalloproteinase
  • IGFBP-4 Protease
  • IGFBP-4-Specific Proteinase
  • Insulin-Like-Growth Factor Binding Protein-4 Protease
  • Insulin-Like Growth Factor-Dependent IGF Binding Protein-4 Protease
  • PAPP-A
  • PAPP-alpha
  • Pregnancy Associated alpha Plasma Protein
  • Pregnancy-Associated alpha-Plasma Protein

Allowable Qualifier(s)

In other languages

URI

http://data.loterre.fr/ark:/67375/JVR-WMJ27G2G-6

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RDF/XML TURTLE JSON-LD Created 2/22/79, last modified 7/13/04