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... > Polycyclic Compounds > Polycyclic Aromatic Hydrocarbons > Naphthalenes > Tetrahydronaphthalenes > Podophyllotoxin > Etoposide
... > Organic Chemicals > Hydrocarbons > Hydrocarbons, Cyclic > Hydrocarbons, Aromatic > Polycyclic Aromatic Hydrocarbons > Naphthalenes > Tetrahydronaphthalenes > Podophyllotoxin > Etoposide
... > Organic Chemicals > Hydrocarbons > Hydrocarbons, Cyclic > Hydrocarbons, Aromatic > Benzene Derivatives > Benzyl Compounds > Lignans > Podophyllotoxin > Etoposide
Carbohydrates > Glycosides > Glucosides > Etoposide

Preferred term

Etoposide  

Type

  • mesh:Descriptor

Definition

  • A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.

Broader concept

Entry terms

  • 100007-53-2 (alpha-D-glucopyranosyl isomer)
  • 33419-42-0 (Etoposide)
  • 6PLQ3CP4P3
  • 89301-95-1 ((5S)-isomer)
  • 96554-38-0 ((5a alpha)-isomer)
  • 96554-41-5 ((5a alpha,9 alpha)-isomer)
  • Demethyl Epipodophyllotoxin Ethylidine Glucoside
  • Eposide

Allowable Qualifier(s)

Pharmacological Action(s)

In other languages

  • Étoposide

    French

  • 100007-53-2 (alpha-D-glucopyranosyl isomer)
  • 33419-42-0 (Etoposide)
  • 6PLQ3CP4P3
  • 89301-95-1 ((5S)-isomer)
  • 96554-38-0 ((5a alpha)-isomer)
  • 96554-41-5 ((5a alpha,9 alpha)-isomer)

URI

http://data.loterre.fr/ark:/67375/JVR-WN4RBMR3-B

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RDF/XML TURTLE JSON-LD Created 7/25/75, last modified 3/1/18