Concept information
Preferred term
2,3-Diphosphoglycerate
Type
-
mesh:Descriptor
Definition
- A highly anionic organic phosphate which is present in human red blood cells at about the same molar ratio as hemoglobin. It binds to deoxyhemoglobin but not the oxygenated form, therefore diminishing the oxygen affinity of hemoglobin. This is essential in enabling hemoglobin to unload oxygen in tissue capillaries. It is also an intermediate in the conversion of 3-phosphoglycerate to 2-phosphoglycerate by phosphoglycerate mutase (EC 5.4.2.1). (From Stryer Biochemistry, 4th ed, p160; Enzyme Nomenclature, 1992, p508)
Broader concept
Entry terms
- 138-81-8
- 14438-19-8 ((D)-isomer)
- 2,3-Bisphosphoglycerate
- 2,3-DPG
- Glycerate 2,3-Bisphosphate
Allowable Qualifier(s)
- administration & dosage (Qualifier)
- adverse effects (Qualifier)
- agonists (Qualifier)
- analysis (Qualifier)
- antagonists & inhibitors (Qualifier)
- blood (Qualifier)
- cerebrospinal fluid (Qualifier)
- chemical synthesis (Qualifier)
- chemistry (Qualifier)
- classification (Qualifier)
- economics (Qualifier)
- history (Qualifier)
- immunology (Qualifier)
- isolation & purification (Qualifier)
- metabolism (Qualifier)
- pharmacokinetics (Qualifier)
- pharmacology (Qualifier)
- poisoning (Qualifier)
- radiation effects (Qualifier)
- standards (Qualifier)
- supply & distribution (Qualifier)
- therapeutic use (Qualifier)
- toxicity (Qualifier)
- urine (Qualifier)
In other languages
-
French
-
138-81-8
-
14438-19-8 ((D)-isomer)
-
2,3-Bisphosphoglycérate
-
2,3-Diphosphoglycérate
-
2,3-DPG
URI
http://data.loterre.fr/ark:/67375/JVR-WP4GVBK8-0
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