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Concept information

Biological Factors > Blood Coagulation Factors > Factor VIII > Factor VIIIa
... > Amino Acids, Peptides, and Proteins > Proteins > Blood Proteins > Blood Coagulation Factors > Factor VIII > Factor VIIIa
Amino Acids, Peptides, and Proteins > Proteins > Protein Precursors > Factor VIII > Factor VIIIa

Preferred term

Factor VIIIa  

Type

  • mesh:Descriptor

Definition

  • Activated form of factor VIII. The B-domain of factor VIII is proteolytically cleaved by thrombin to form factor VIIIa. Factor VIIIa exists as a non-covalent dimer in a metal-linked (probably calcium) complex and functions as a cofactor in the enzymatic activation of factor X by factor IXa. Factor VIIIa is similar in structure and generation to factor Va.

Broader concept

Related concepts

Entry terms

  • 72175-66-7
  • Blood Coagulation Factor VIII, Activated
  • Blood-coagulation factor VIIIa, procoagulant
  • Coagulation Factor VIIIa
  • Factor 8A
  • Factor Eight A
  • Factor VIII, Activated
  • Factor VIII, Thrombin-Activated

Allowable Qualifier(s)

In other languages

  • Facteur VIIIa

    French

  • 72175-66-7
  • Blood-coagulation factor VIIIa, procoagulant
  • Facteur antihémophilique A activé
  • Facteur VIII activé
  • Facteur VIII activé par la thrombine
  • Facteur VIIIa de la coagulation
  • Facteur VIIIa de la coagulation sanguine

URI

http://data.loterre.fr/ark:/67375/JVR-XB7BBVD9-P

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RDF/XML TURTLE JSON-LD Created 5/25/89, last modified 5/30/19